I've been using Microsoft 365 on Windows 11 as well, and I can relate to some of the challenges you've mentioned. OneDrive sync can occasionally act up, especially if there's a large number of files or if the internet connection is unstable. A tip that often helps is to ensure that OneDrive is set to always start with Windows and to check that you're using the latest version. Sometimes, temporarily pausing the sync and then resuming can resolve minor issues.
As for Excel lagging with large spreadsheets, this seems to be a common issue. Two things I found useful are enabling hardware acceleration — which can be done under Excel Options in the Advanced section — and checking for any add-ins that might be slowing down Excel. Disabling unnecessary add-ins can improve performance.
Overall, keeping your system updated and clearing cache files regularly can help maintain smooth operations. If the problems persist, consider reaching out to Microsoft Support for more tailored help. Keep an eye on forums like these, as they often have shared experiences and solutions from other users!